Nanjing Drum Tower Hospital, Clinical Medical College of Traditional Chinese and Western Medicine, Nanjing University of CM, Nanjing 210029, Jiangsu Province, China（南京中医药大学中西医结合鼓楼临床医学院，江苏南京 210029）
Corresponding author: XU Tian-shu (1967-), female, chief physician. Research field: modern study on acupuncture and moxibustion theory.
First author: XU Lin-ling (1967-), female, postgraduate student.
Accepted on July 16, 2015
Objective To observe the clinical efficacy of grain-shaped moxibustion in reinforcing healthy qi and dispelling pathogen and to explore the possible mechanisms of grain-shaped moxibustion in improving immune function of patients through determining the expression level of IL-12 in peripheral blood of patients. Methods Seventy patients undergoing chemotherapy due to deficiency of both qi and blood type of malignant tumor in the departments of traditional Chinese medicine and oncology in Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School from January 2014 to January 2015 were randomly divided into a chemotherapy group (group A) and a chemotherapy combined with grain-shaped moxibustion group (group B) by sortition, 35 cases in each one. Patients in both groups received chemotherapy, while patients in group B also received grain-shaped moxibustionat on bilateral Zúsānlǐ (足三里 ST 36), which was performed once daily, 7 cones every time, for a total of continuous 20 days. Before and after treatment, the expression level of IL-12 in peripheral blood of patients was determined using ELISA method. Results After chemotherapy, the expression level of IL-12 in patients was significantly lower than that before treatment. After two courses of adjuvant therapy of grain-shaped moxibustion, the expression level of IL-12 in chemotherapy patients slightly increased and the difference was statistically significant (P<0.05). Conclusion Grain-shaped moxibustion can increase the expression of IL-12 in peripheral blood of patients, promote the T cell-mediated immune response and achieve immunoregulation and anti-tumor effects.
KEY WORDS: grain-shaped moxibustion therapy; malignant tumor; chemotherapy; IL-12 ABSTRACT IN CHINESE
[摘 要] 目的：通过测定恶性肿瘤患者外周血中IL-12表达水平的变化，观察麦粒灸扶正祛邪的临床疗效，探索麦粒灸提高恶性肿瘤患者免疫功能的可能机制。方法：将2014年1月—2015年1月就诊于南京大学医学院附属鼓楼医院中医科及肿瘤科的气血两虚型恶性肿瘤化疗患者70例抽签法随机分为基础化疗组（A组）及基础化疗加麦粒灸组（B组），每组30例。两组均行基础化疗，麦粒灸组患者还要接受在双侧足三里穴上施以麦粒灸，每天1次，每次7壮，治疗持续20天。在治疗前及治疗结束时运用ELISA法测定患者外周血中IL-12的表达水平。结果：发现化疗后气血两虚型恶性肿瘤患者IL-12的表达较化疗前明显降低，经麦粒灸辅助治疗两疗程后，B组化疗患者的IL-12表达水平稍有提高，差异有统计学意义（P<0.05）。结论：麦粒灸能增强气血两虚型恶性肿瘤患者外周血中IL-12的表达，促进T细胞介导的免疫应答，实现免疫调节和抗肿瘤效应。
[关键词] 麦粒灸疗法 恶性肿瘤 化疗 IL-12